In chemistry, a leaving group is a molecular fragment that departs with a pair of electrons in heterolytic bond cleavage. Leaving groups can be anions or neutral molecules, but in either case it is crucial that the leaving group be able to stabilize the additional electron density that results from bond heterolysis.Click to see full answer. In this regard, what makes a good leaving group in an sn2 reaction?Good leaving groups are weak bases. They’re happy and stable on their own. Some examples of weak bases: halide ions (I-, Br-, Cl-) water (OH2), and sulfonates such as p-toluenesulfonate (OTs) and methanesulfonate (OMs). The weaker the base, the better the leaving group.Likewise, why is oh a bad leaving group? Alcohols have hydroxyl groups (OH) which are not good leaving groups. Why not? Because good leaving groups are weak bases, and the hydroxide ion (HO–) is a strong base. This will convert the alcohol into an alkyl bromide or alkyl chloride, respectively, and halides (being weak bases) are great leaving groups. One may also ask, is Cl or Br a better leaving group? Bromine is a better leaving group than Cl since it is a weaker base than | Course Hero.What makes a nucleophile strong?The key factors that determine the nucleophile’s strength are charge, electronegativity, steric hindrance, and nature of the solvent. Nucleophilicity increases as the density of negative charge increases.
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